Sperm Nuclear Maturation
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Product Information
| ISBN | 9781616681944 |
|---|---|
| Publisher | Nova Science Publishers Inc |
| Publishing Date | 21/10/2011 |
| Price (excl. tax) | €66.89 |
| Tax | €4.01 |
| Price (incl. tax) | €70.90 |
| Availability | 1 unit in external warehouse |
Product Description
In somatic cells, DNA is normally wrapped around the histones octamer to forms nucleosomes that eventually give rise to a solenoid DNA structure. Unlike somatic cells, in mammalian sperm, the development of spermatids into mature spermatozoa is accomplished by a series of structural and chemical modifications including a gradual replacement of lysine-rich histones by transition proteins and then by protamines which bind more tightly to DNA than histones, which results in compaction of chromatin in the sperm nucleus, a process which is termed ''sperm chromatin condensation''. This book examines the several techniques that have been devised in order to study chromatin and DNA defects in human spermatozoa.